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Some websites offer medications without a prescription or a doctor review. This practice has been criticized as potentially dangerous, especially by those who feel that only doctors can reliably assess contraindications, risk/benefit ratios, and the suitability of a medication for a specific individual. Pharmacies offering medication without a prescription and doctor review or supervision are sometimes fraudulent. In the United States, there has been a push to legalize importation of medications from Canada and several European countries, in order to reduce consumer costs. Although importation of prescription medication usually violates Food and Drug Administration (FDA) regulations and federal laws, enforcement is generally targeted at international drug suppliers, rather than consumers. Often Americans purchase lower-cost foreign drugs by driving to Canadian or Mexican pharmacies, buying their medications when traveling abroad on vacation, or, buying from foreign pharmacies that ship their orders via mail. International consumers often purchase drugs online from online pharmacies in their own countries, or those located in other nations such as India, Pakistan and the Philippines. Some of these pharmacies require prescriptions, while others do not. Of those which do not require prescriptions, some do ask the customer to fill in a health questionnaire with their order. Drugs available online are often produced by well-known manufacturers such as Pfizer, Wyeth, Roche, and generic Indian drugmakers Cipla and Ranbaxy and Teva Pharmaceutical Industries of Israel.

It is a fairly common practice for North American and European visitors to countries like Thailand, India and South Africa to purchase and bring home affordable medications for themselves, family members and/or friends.[citation needed] Savings can be significant, often exceeding 80 percent compared to the same medications available in their home countries. Travellers may avoid possible difficulties inherent to physically going through customs with their medication purchases by mailing the drugs to their home so they receive them upon their return. o save money, millions of uninsured and underinsured U.S. consumers purchase drugs from online pharmacies in Canada, India, the UK and other countries and receive their purchases by mail. Especially for uninsured Americans taking prescription drugs for chronic health conditions, a major attraction of online pharmacies abroad is that nearly every country, except the U.S., controls its drug prices. Shoppers can easily obtain 50 to 80 percent or more savings at foreign pharmacies, in comparison to US prices.

Very rarely are these orders investigated because U.S. authorities are much more worried about controlling illegal pharmacies in the U.S., not consumers themselves. In fact, the Washington Post reported that ". millions of Americans have turned to Mexico and other countries in search of bargain drugs.U.S. Customs estimates 10 million U.